VX-702 , >98.0%(HPLC) , 745833-23-2
CAS NO.:745833-23-2
Empirical Formula: C19H12F4N4O2
Molecular Weight: 404.32
MDL number: MFCD11616590
Pack Size | Price | Stock | Quantity |
25mg | RMB280.00 | In Stock |
|
100mg | RMB792.00 | In Stock |
|
others | Enquire |
PRODUCT Properties
Boiling point: | 555.2±60.0 °C(Predicted) |
Density | 1.503 |
storage temp. | -20°C |
solubility | Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 2 mg/ml) |
form | solid |
pka | 10.65±0.50(Predicted) |
color | White |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
CAS DataBase Reference | 745833-23-2 |
Description and Uses
VX-
VX-702 is a third generation inhibitor of p38 mitogen-activated protein (MAP) kinases, binding to both p38α and p38β (Kd = 3.7 and 17 nM, respectively) in an ATP-competitive fashion. It inhibits IL-6, IL-1β, and TNF-α production in LPS-primed blood with IC50 values of 59, 122, and 99 ng/ml, respectively. VX-702, at 1 μM, inhibits activation of p38 in platelets by thrombin, U-46619 , or collagen but does not block platelet aggregation in response to collagen. Although orally active, VX-702 provides only transient suppression of biomarkers of inflammation in ongoing rheumatoid arthritis.[Cayman Chemical]
Safety
Symbol(GHS) | GHS07 |
Signal word | Warning |
Hazard statements | H315-H319 |
Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
HS Code | 2933399990 |