Home Categories Biochemical Engineering SCH772984
A7368812

SCH772984 , ≥98% , 942183-80-4

CAS NO.:942183-80-4

Empirical Formula: C33H33N9O2

Molecular Weight: 587.67

MDL number: MFCD11878503

EINECS: 1592732-453-0

Pack Size Price Stock Quantity
1MG RMB231.20 In Stock
5MG RMB799.20 In Stock
10MG RMB1295.20 In Stock
25MG RMB2591.20 In Stock
50MG RMB4607.20 In Stock
100mg RMB6143.20 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: >214°C (dec.)
Boiling point: 857.3±65.0 °C(Predicted)
Density  1.353±0.06(20.0000℃)
storage temp.  Refrigerator
solubility  DMSO (Slightly)
pka 12.05±0.40(Predicted)
form  Solid
color  Pale Yellow
CAS DataBase Reference 942183-80-4

Description and Uses

The extracellular regulated kinases 1 and 2 (ERK1/2) are functionally redundant kinases activated by a variety of growth factors and mitogens. SCH 772984 is a potent inhibitor of ERK1 and ERK2 (IC50s = 4 and 1 nM, respectively). It is highly selective, with only seven kinases of 300 tested showing more than 50% inhibition at a concentration of 1 μM. SCH 772984 has nanomolar cytotoxicity in tumor cells with mutations in BRAF, NRAS, or KRAS. It is effective in vivo, inducing regression of xenograft tumors in mice. SCH 772984 displays slow binding kinetics, binding to a novel binding pocket in inactive ERK isoforms.

SCH772984 is a novel and selective inhibitor of ERK1/2 that displays behaviors of both type I and type II kinase inhibitors and has nanomolar cellular potency in tumor cells with mutations in BRAF, NRA5, or KRAS and induces tumor regressions in xenograft models.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  29339900

RELATED PRODUCTS