SB-203580 , ≥98%(HPLC) , 152121-47-6

Synonym(s):
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole;4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, p38 MAP Kinase Inhibitor XVI;SB 203580 - CAS 152121-47-6 - Calbiochem

CAS NO.：152121-47-6

Empirical Formula: C21H16FN3OS

Molecular Weight: 377.43

MDL number: MFCD00922198

PRODUCT Properties

• Melting point: 144-146
• Boiling point: 615.6±55.0 °C(Predicted)
• Density: 1.4
• storage temp.: -20°C
• solubility: DMSO: 50 mg/mL
• form: solid
• pka: 9.60±0.10(Predicted)
• color: white to off-white
• Stability: -200C
• InChIKey: CDMGBJANTYXAIV-UHFFFAOYSA-N

Description and Uses

SB 203580 (152121-47-6) is a potent and selective inhibitor of p38 MAP kinase, IC50=50 and 500 nM for p38 and p38β2 respectively.1 No other kinases (in a panel of 30) were significantly inhibited including p38γ and δ at 10 μM.2?A potent inhibitor of inflammatory cytokine production (IC50=15-25 mg/kg in mice and rats) in animal models of arthritis, bone resorption, endotoxin shock and immune function.3

MDCK cells were treated with SB 203580 to study the role of MAPK signaling in inducing hypertonicity of cell membrane and potassium depletion.¹⁶ It was used to inhibit MAPK signaling in mouse cortical neurons¹⁷ and human hepatocellular carcinoma cell lines.¹⁸

Safety

• Symbol(GHS): GHS05,GHS07
• Signal word: Danger
• Hazard statements: H302-H318
• Precautionary statements: P264-P270-P280-P301+P312-P305+P351+P338-P501
• Hazard Codes: Xn
• Risk Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• HS Code: 29333990