PD98059 , ≥98% , 167869-21-8
Synonym(s):
2ʹ-Amino-3ʹ-methoxyflavone, MEK Inhibitor V;2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one;MEK Inhibitor V
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB425.60 | In Stock |
|
| 50MG | RMB2305.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 164～165℃ |
| Boiling point: | 453.1±45.0 °C(Predicted) |
| Density | 1.300±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | ethanol: 0.6 mg/mL |
| form | solid |
| pka | 1.21±0.10(Predicted) |
| color | yellow |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChIKey | QFWCYNPOPKQOKV-UHFFFAOYSA-N |
Description and Uses
PD 98059 is a noncompetitive inhibitor of the MAPK pathway. It prevents the activation of MEK by Raf or MEK kinase (a MAP3K) with an IC50 value of 2-7 μM but does not inhibit Raf-activated MAP2K1. It inhibits Raf activation of MAP2K2 with an IC50 value of 50 μM. PD 98059 also phosphorylates and activates AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 35 μM in HEK293 cells). It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).
PD 98059 is a selective inhibitor of MEK and blocker of MAPK.
