LY294002 , ≥98% , 154447-36-6

Synonym(s):
2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride;2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV;PI3K inhibitor

CAS NO.：154447-36-6

Empirical Formula: C19H17NO3

Molecular Weight: 307.34

MDL number: MFCD01530034

EINECS: 1312995-182-4

PRODUCT Properties

• Melting point: 183-185℃
• Boiling point: 494.6±45.0 °C(Predicted)
• Density: 1.266
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: DMSO: >5 mg/mL
• form: solid
• pka: 0.55±0.20(Predicted)
• color: white to off-white
• Water Solubility: Soluble in DMSO at 5mg/ml. Insoluble in water
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
• InChIKey: CZQHHVNHHHRRDU-UHFFFAOYSA-N
• CAS DataBase Reference: 154447-36-6

Description and Uses

LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC₅₀ of 1.4 μM.

LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302-H320-H361-H370-H372-H336-H402
• Precautionary statements: P501-P273-P260-P270-P202-P201-P271-P264-P280-P337+P313-P305+P351+P338-P308+P311-P301+P312+P330-P304+P340+P312-P403+P233-P405
• Safety Statements: 24-25
• WGK Germany: 3
• HS Code: 29349990