A7364612
SP600125 , ≥98% , 129-56-6
Synonym(s):
1,9-Pyrazoloanthrone;Anthrapyrazolone;JNK Inhibitor II - CAS 129-56-6 - Calbiochem;SAPK Inhibitor II, Anthra[1,9- cd]pyrazol-6(2 H)-one, 1,9-pyrazoloanthrone, SP600125
CAS NO.：129-56-6
Empirical Formula: C14H8N2O
Molecular Weight: 220.23
MDL number: MFCD00022289
EINECS: 204-955-6
| Pack Size | Price | Stock | Quantity |
| 25MG | RMB87.20 | In Stock |
|
| 100MG | RMB172.80 | In Stock |
|
| 500MG | RMB262.40 | In Stock |
|
| 1g | RMB368.00 | In Stock |
|
| 5g | RMB1100.80 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 281~282℃ |
| Boiling point: | 361.16°C (rough estimate) |
| Density | 1.1702 (rough estimate) |
| refractive index | 1.5910 (estimate) |
| storage temp. | 2-8°C |
| solubility | H2O: insoluble |
| form | Yellowish orange solid |
| pka | 11.75±0.20(Predicted) |
| color | yellow |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months |
| InChIKey | ACPOUJIDANTYHO-UHFFFAOYSA-N |
Description and Uses
SP-600125 (129-56-6) is a selective inhibitor of c-Jun N-terminal kinase (JNK). Reversibly inhibits JNK1,2 and 3 (IC50‘s range from 40-90 nM). >300-fold selectivity for JNK as compared to related MAP kinases. Anti-inflammatory activity. SP-600125 inhibits expression of presenilin-1 and Notch signaling in mouse brain. Cell permeable and active in vivo.
SP 600125 is a Jun N-terminal kinase (JNK) inhibitor.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | CB4585000 |
| TSCA | Yes |
| HS Code | 29339900 |
| Toxicity | LD50 ivn-mus: 178 mg/kg CSLNX* NX#00640 |
