1-pheny-3-methyl-5-pyrazolone , 99% , 89-25-8
Synonym(s):
Edaravone;1-Phenyl-3-methyl-5-pyrazolone;3-Methyl-1-phenyl-2-pyrazolin-5-one;3-Methyl-1-phenyl-2-pyrazoline-5-one;5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
CAS NO.：89-25-8
Empirical Formula: C10H10N2O
Molecular Weight: 174.2
MDL number: MFCD00003138
EINECS: 201-891-0
| Pack Size | Price | Stock | Quantity |
| 100G | RMB42.40 | In Stock |
|
| 500G | RMB149.60 | In Stock |
|
| 2.5KG | RMB531.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 126-128 °C(lit.) |
| Boiling point: | 287 °C265 mm Hg(lit.) |
| Density | 1,12 g/cm3 |
| vapor pressure | 0.016Pa at 20℃ |
| refractive index | 1.6300 (estimate) |
| Flash point: | 191°C/17mm |
| storage temp. | 2-8°C |
| solubility | 3.30g/l |
| form | Crystalline Powder |
| pka | 2.73±0.50(Predicted) |
| color | Yellow to beige |
| PH | 4.0-4.4 (H2O, 20℃)(saturated aqueous solution) |
| Water Solubility | 3 g/L (20 ºC) |
| Merck | 14,6713 |
| BRN | 609575 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChIKey | QELUYTUMUWHWMC-UHFFFAOYSA-N |
| LogP | 0.75 at 24℃ |
Description and Uses
Edaravone was marketed in Japan for improving neurologic recovery following acute brain infarction. Currently, several agents classified as neuroprotectants and acting by diverse mechanisms (inhibition of glutamate release, blockade of calcium channels, lazaroids) have been marketed for treating the outcomes of brain damage due to trauma, ischemia or cardiac arrest. Edavarone is the first antioxidant with free radical scavenging activity to be introduced for this pathology. This previously described molecule (in particular as norantipyrine, one of three metabolites of antipyrine in mammals) can be simply prepared by direct cyclization of phenylhydrazine with alkylacetoacetate. Edarevone is a lipophilic agent, readily accessible to brain tissue, that is capable of reducing edema in the brain following ischemia by blocking the arachidonic acid cascade triggering peroxidative neurodegeneration. Interestingly, this agent has been shown to quench active oxygen species in endothelial cell homogenate, as well as inhibiting in vitro lipid peroxidative disintegration of membranes, so making this compound effective during reperfusion following ischemic injury. As an additional indication, phase III trials started with edaravone for increasing the chance of recovery after subarachnoid hemorrhage.
3-Methyl-1-phenyl-2-pyrazolin-5-one used as reagent for detection of reducing carbohydrates by ESI/MALDI -MS.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H319 |
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 1 |
| RTECS | UQ9625000 |
| TSCA | Yes |
| HS Code | 29331990 |
| Toxicity | LD50 orl-rat: 3500 mg/kg LONZA# 08FEB79 |
