SB 202190 , 99% , 152121-30-7

Synonym(s):
4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole;4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, FHPI, p38 MAP Kinase Inhibitor II;InSolution p38 MAP Kinase Inhibitor II;InSolution SB 202190 - CAS 152121-30-7 - Calbiochem;SB 202190 - CAS 152121-30-7 - Calbiochem

CAS NO.：152121-30-7

Empirical Formula: C20H14FN3O

Molecular Weight: 331.34

MDL number: MFCD00941964

PRODUCT Properties

• Melting point: 240-243℃
• Boiling point: 565.7±50.0 °C(Predicted)
• Density: 1.31
• RTECS: SL4584000
• storage temp.: 2-8°C
• solubility: DMSO: 30 mg/mL, soluble
• pka: 9.14±0.15(Predicted)
• form: Pale yellow solid
• color: pale yellow
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
• InChIKey: QHKYPYXTTXKZST-UHFFFAOYSA-N

Description and Uses

SB 202190 is a selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC₅₀ values of 50 and 100 nM, respectively. When tested at 10 μM, SB 202190 has negligible effects on a range of other kinases, including other MAP kinases (ERKs, JNKs). Pyridinyl imidazole inhibitors, including this compound, directly bind p38 MAP kinases in the ATP binding pocket. Recently, SB 202190 has been used to elucidate the roles of p38 MAP kinases in inflammatory cytokine expression, nicotine-induced receptor expression, and HIV-mediated depressive disorder.

SB 202190 is a DFG inhibitor used in the treatment of colorectal cancer. It is a highly selective, potent inhibitor of p38 MAP kinase. SB-202190 is able to promote proliferation of C6 cells in lower concentration but induced apoptosis in higher levels. Studies show that SB202190 can protect neural function from ischemia/reperfusion injury and regulate the activation of Bcl-2 and Bax protein after ischemia/reperfusion in rat.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 3
• HS Code: 29333990