DuP-697 , 98% , 88149-94-4

CAS NO.：88149-94-4

Empirical Formula: C17H12BrFO2S2

Molecular Weight: 411.31

MDL number: MFCD02684527

PRODUCT Properties

• storage temp.: 2-8°C
• solubility: DMF: 54 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 15 mg/ml; Ethanol: 7 mg/ml
• form: White to off-white solid.
• color: White to off-white

Description and Uses

DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2. When tested on isolated recombinant enzymes, DuP-697 is at least 50 times more potent in the inhibition of COX-2 than COX-1. The IC₅₀ values for human recombinant COX-2 are 80 and 40 nM at 5 and 10 minutes, respectively. The IC₅₀ for the inhibition of human recombinant COX-1 after the same time intervals is 9 μM. DuP-697 also attenuates the COX-1 inhibitory activity of non-selective COX inhibitors such as indomethacin.

DuP-697 is a thiophene that inhibits COX-2 and acts as a NSAID.

Safety

• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36