Home Categories API Indomethacin
A4989412

Indomethacin , 99% , 53-86-1

Synonym(s):
1-( p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid;1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid;1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid;IDM;Indomethacin - CAS 53-86-1 - Calbiochem

CAS NO.:53-86-1

Empirical Formula: C19H16ClNO4

Molecular Weight: 357.79

MDL number: MFCD00057095

EINECS: 200-186-5

Pack Size Price Stock Quantity
5G RMB37.60 In Stock
25G RMB80.00 In Stock
100G RMB190.40 In Stock
500G RMB628.00 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: 158-162 °C
Boiling point: 499.4±45.0 °C(Predicted)
Density  1.2135 (rough estimate)
refractive index  1.6800 (estimate)
storage temp.  Store at RT
solubility  ethanol: 50 mg/mL, clear, yellow-green
pka 4.5(at 25℃)
form  White to off-white powder
color  White to Light yellow to Light orange
Water Solubility  Soluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.
Sensitive  Light Sensitive
Merck  14,4968
BRN  497341
BCS Class 2
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey CGIGDMFJXJATDK-UHFFFAOYSA-N
CAS DataBase Reference 53-86-1(CAS DataBase Reference)
NIST Chemistry Reference Indomethacin(53-86-1)
EPA Substance Registry System Indomethacin (53-86-1)

Description and Uses

Aqueous solutions of indomethacin are not stable because of the ease of hydrolysis of the p-chlorobenzoyl group. The original synthesis of indomethacin by Shen et al. involved the formation of 2-methyl-5-methoxyindole acetic acid and subsequent acylation after protection of the carboxyl group as the t-butyl ester. It was introduced in the United States in 1965. It is still one of the most potent NSAIDs in use. It also is a more potent antipyretic than either aspirin or acetaminophen, and it possesses approximately 10 times the analgetic potency of aspirin.

Indomethacin is used in rheumatoid arthritis, nonspecific infectious polyarthritis, gouty arthritis, osteoarthritis, ankylosing spondylitis, arthrosis, back pain, neuralgia, myalgia, and other diseases accompanied by inflammation.

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P264-P301+P310
Hazard Codes  T+,Xi,T
Risk Statements  28-36/37/38-39/23/24/25-23/24/25
Safety Statements  28-36/37-45-36-26
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS  NL3500000
8-10
TSCA  Yes
HazardClass  6.1
PackingGroup  I
HS Code  29339900
Hazardous Substances Data 53-86-1(Hazardous Substances Data)
Toxicity LD50 i.p. in rats: 13 mg/kg (Klaassen)

RELATED PRODUCTS