Piroxicam , ≥98%(HPLC) , 36322-90-4

Synonym(s):
4-Hydroxy-2-methyl-3-(pyrid-2-yl-carbamoyl)-2H-1,2-benzothiazine 1,1-dioxide;Piroxicam

CAS NO.：36322-90-4

Empirical Formula: C15H13N3O4S

Molecular Weight: 331.35

MDL number: MFCD00057317

EINECS: 252-974-3

PRODUCT Properties

• Melting point: 198-200°C
• Density: 1.3664 (rough estimate)
• refractive index: 1.6320 (estimate)
• storage temp.: 2-8°C
• solubility: Practically insoluble in water, soluble in methylene chloride, slightly soluble in anhydrous ethanol. It shows polymorphism (5.9).
• pka: 6.3 (2:1 dioxane-water)
• form: Solid
• color: White to Light yellow
• Water Solubility: Soluble in water, ethanol, chloroform, ethyl acetate.
• λmax: 358nm(H2O)(lit.)
• Merck: 14,7506
• BCS Class: 2
• InChIKey: QYSPLQLAKJAUJT-UHFFFAOYSA-N

Description and Uses

Piroxieam is a non-steroidal anti-inflammatory drug, of the oxieam class. A contact and photocontact sensitizer, which induced contact dermatitis in a physieal therapist. Piroxieam generally cross reacts with thiosalicylic acid and also with thiomersal. Cross sensitivity is not observed to tenoxicam.

Piroxicam is used in inflammatory and degenerative diseases of the musculoskeletal system that are accompanied by painful symptoms. It is used for rheumatic heart disease, nonspecific infectious polyarthritis, gouty arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, arthrosis, back pain, neuralgia, myalgia, and other diseases associated with inflammation.

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H301-H373
• Precautionary statements: P260-P264-P270-P301+P310-P314-P405
• Hazard Codes: Xn,F,T
• Risk Statements: 22-25
• Safety Statements: 26-36
• RIDADR: UN 2811
• WGK Germany: 3
• RTECS: DL0705000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29349990
• Toxicity: LD50 orally in mice: 360 mg/kg (Wiseman)