Lornoxicam , 2mMinDMSO , 70374-39-9
Synonym(s):
6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide;Chlortenoxicam;Ro 13-9297;TS 110
CAS NO.：70374-39-9
Empirical Formula: C13H10ClN3O4S2
Molecular Weight: 371.82
MDL number: MFCD00866163
EINECS: 630-354-7
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 225-230°C (dec.) |
| Density | 1.742±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO: >5mg/mL (warmed) |
| pka | pKa2 4.7(at 25℃) |
| form | powder |
| color | faint yellow to dark yellow |
| Merck | 14,5582 |
| InChI | InChI=1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19) |
| InChIKey | WLHQHAUOOXYABV-UHFFFAOYSA-N |
| SMILES | S1(=O)(=O)C2C=C(Cl)SC=2C(O)=C(C(NC2=NC=CC=C2)=O)N1C |
Description and Uses
Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 (TXB2; ) from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in HEL human erythroleukemic cells (IC50 = 3 nM), which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α (PGF1α; ) from arachidonic acid in Mono-Mac-6 cells (IC50 = 8 nM), which endogenously express COX-2. Lornoxicam reduces LPS-induced production of nitric oxide and IL-6 in cell-based assays with IC50 values of 65 and 54 μM, respectively. It reduces carrageenan-induced paw edema in rats when administered intravenously at doses ranging from 0.1 to 9 mg/kg. Formulations containing lornoxicam have been used in the management of postoperative pain.
For the treatment of acute mild to moderate pain, as well as pain and inflammation of the joints caused by certain types of rheumatic diseases.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300 |
| Precautionary statements | P264-P301+P310 |
| Hazard Codes | Xi,T+ |
| Risk Statements | 36/37/38-28 |
| Safety Statements | 26-36-45-36/37-28 |
| RIDADR | UN 2811 6.1 / PGII |
| WGK Germany | 3 |
| RTECS | XJ9095000 |
| HazardClass | IRRITANT |
| PackingGroup | II |
| HS Code | 29349990 |
| Toxicity | LD50 orally in mice, rats, rabbits, dogs, monkeys: >10 mg/kg (Pruss) |
