NS398 , 10mMinDMSO , 123653-11-2

Synonym(s):
N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide;N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide;NS-398 - CAS 123653-11-2 - Calbiochem

CAS NO.：123653-11-2

Empirical Formula: C13H18N2O5S

Molecular Weight: 314.36

MDL number: MFCD00882995

PRODUCT Properties

• Melting point: 124-126 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling point: 490.6±55.0 °C(Predicted)
• Density: 1.377±0.06 g/cm3(Predicted)
• RTECS: PB0473500
• storage temp.: Sealed in dry,Room Temperature
• solubility: DMSO: >5 mg/mL
• form: solid
• pka: 6.33±0.10(Predicted)
• color: off-white

Description and Uses

NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC₅₀ values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively. The IC₅₀ values for ovine COX-1 and -2 are 220 and 0.15 μM, respectively.

NS-398 is a selective Cox-2 inhibitor neuroprotective agent.

Safety

• Safety Statements: 22-24/25
• WGK Germany: 3
• HS Code: 2935.90.9500