Home Categories Analytical Chemistry Cylindrospermopsin
M7995347

Cylindrospermopsin , 98% , 143545-90-8

CAS NO.:143545-90-8

Empirical Formula: C15H21N5O7S

Molecular Weight: 415.425

MDL number: MFCD01939922

Pack Size Price Stock Quantity
50μg RMB4798.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Density  1.3937 (rough estimate)
refractive index  1.6460 (estimate)
storage temp.  −20°C
solubility  DMSO: soluble
form  white powder
pka -3.78±0.18(Predicted)
EPA Substance Registry System Cylindrospermopsin (143545-90-8)

Description and Uses

Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 μM, respectively), leading to cell death. It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 μM. Cylindrospermopsin is genotoxic, inducing DNA damage as evidenced by double strand breaks and reducing cell viability in HepG2 cells at 0.1-0.5 μg/ml.

Cylindrospermopsin is a cyanotoxin produced by cyanobacterial species and found in many bodies of water.

Safety

Symbol(GHS) 
GHS08,GHS06
Signal word  Danger
Hazard statements  H341-H300-H370
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501-P201-P202-P281-P308+P313-P405-P501
WGK Germany  3
RTECS  UV9104310
Hazardous Substances Data 143545-90-8(Hazardous Substances Data)
Toxicity mouse,LD50,intraperitoneal,2100ug/kg (2.1mg/kg),LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"BLOOD: CHANGES IN SPLEENKIDNEY, URETER, AND BLADDER: OTHER CHANGES,Toxicologist. Vol. 14, Pg. 211, 1994.

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