Cylindrospermopsin , 98% , 143545-90-8
CAS NO.：143545-90-8
Empirical Formula: C15H21N5O7S
Molecular Weight: 415.425
MDL number: MFCD01939922
| Pack Size | Price | Stock | Quantity |
| 50μg | RMB4798.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Density | 1.3937 (rough estimate) |
| refractive index | 1.6460 (estimate) |
| storage temp. | −20°C |
| solubility | DMSO: soluble |
| form | white powder |
| pka | -3.78±0.18(Predicted) |
Description and Uses
Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 μM, respectively), leading to cell death. It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 μM. Cylindrospermopsin is genotoxic, inducing DNA damage as evidenced by double strand breaks and reducing cell viability in HepG2 cells at 0.1-
Cylindrospermopsin is a cyanotoxin produced by cyanobacterial species and found in many bodies of water.
Safety
| Symbol(GHS) |   GHS08,GHS06 |
| Signal word | Danger |
| Hazard statements | H341-H300-H370 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501-P201-P202-P281-P308+P313-P405-P501 |
| WGK Germany | 3 |
| RTECS | UV9104310 |
| Toxicity | mouse,LD50,intraperitoneal,2100ug/kg (2.1mg/kg),LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"BLOOD: CHANGES IN SPLEENKIDNEY, URETER, AND BLADDER: OTHER CHANGES,Toxicologist. Vol. 14, Pg. 211, 1994. |
