microcystin lr , 10ug/mlinmethanol , 101043-37-2

Synonym(s):
Cyanoginosin;Fast-death factor;MCYST-LR;Microcystin-LR, Microcystis aeruginosa - CAS 101043-37-2 - Calbiochem

CAS NO.：101043-37-2

Empirical Formula: C49H74N10O12

Molecular Weight: 995.17

MDL number: MFCD00871766

EINECS: 621-323-9

PRODUCT Properties

• Density: 1.29±0.1 g/cm3(Predicted)
• Flash point: 11 °C
• storage temp.: −20°C
• solubility: ethanol: 1 mg/mL
• form: solid film
• pka: 3.03±0.70(Predicted)
• color: Off-white
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol or ethanol may be stored at -20°C for up to 2 months.
• IARC: 2B (Vol. 94) 2010
• EPA Substance Registry System: Microcystin LR (101043-37-2)

Description and Uses

Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria. They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC₅₀= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM. The PP1 IC₅₀ is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H300+H310-H315-H317-H319-H335
• Precautionary statements: P261-P262-P280-P301+P310-P302+P352+P310-P305+P351+P338
• Hazard Codes: T+,T,F
• Risk Statements: 26/27/28-36/37/38-43-39/23/24/25-23/24/25-11
• Safety Statements: 26-36/37/39-45-36/37-16-7
• RIDADR: UN 2811 6.1/PG 1
• WGK Germany: 3
• RTECS: GT2810000
• HS Code: 30029090
• Hazardous Substances Data: 101043-37-2(Hazardous Substances Data)
• Toxicity: LD50 orl-rat: >5 mg/kg HETOEA 18,162,1999