≥98%(HPLC) , 606-59-7

Synonym(s):
2-amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid;Cinnabaric acid

CAS NO.：606-59-7

Empirical Formula: C14H8N2O6

Molecular Weight: 300.22

MDL number: MFCD18379297

PRODUCT Properties

• Melting point: >300°C
• Density: 1.79
• storage temp.: 2-8°C
• solubility: DMSO: ≥4mg/mL
• form: powder
• color: red to very dark red
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.

Description and Uses

Cinnabarinic acid is a phenoxazinone produced by the oxidative dimerization of 3-hydroxyanthranilic acid (3-HAA) as part of the metabolism of tryptophan in the kynurenic pathway. It acts as a partial receptor agonist of the metabotropic glutamate receptor 4 (mGlu4), effective at 100 μM, with no activity at other mGlu receptor subtypes. 3-HAA does not affect mGlu receptors, including mGlu4. Cinnabarinic acid induces apoptosis of T cells at 300-500 μM, a potency some ten times that of 3-HAA.

Cinnabarinic acid may be used in studies of the functions of components of the kynurenine metabolic pathway. It may be used to study it role as a metabotropic glutamate receptor (mGlu4R-specific) agonist.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338
• WGK Germany: 3