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M6257135

Valacyclovir , 98% , 124832-26-4

CAS NO.:124832-26-4

Empirical Formula: C13H20N6O4

Molecular Weight: 324.34

MDL number: MFCD01861507

EINECS: 1312995-182-4

Pack Size Price Stock Quantity
10mg RMB336.00 In Stock
50mg RMB934.40 In Stock
250mg RMB3270.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Density  1.55±0.1 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  Soluble in DMSO
form  Powder
pka 9.34±0.20(Predicted)
EPA Substance Registry System L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester (124832-26-4)

Description and Uses

Valaciclovir (also known as BW256U87 or valaciclovir, and marketed under the trade name of Valtrexs by GlaxoSmithKline) is the hydrochloride salt of the L-valyl ester of aciclovir that was developed originally by Wellcome Research Laboratories. This aciclovir prodrug is rapidly and virtually completely converted to aciclovir following oral administration. As oral administration of valaciclovir results in aciclovir plasma levels nearly equivalent to those achieved by intravenous administration, its efficacy is superior to that of oral aciclovir for the treatment of zoster and equivalent to oral aciclovir in the treatment of first and recurrent episodes of genital herpes.

The L-Valine ester prodrug of Acyclovir.

Valacyclovir (Valtrex) is the 1-valine ester (prodrug) of acyclovir that exhibits no activity until hydrolyzed in the intestinal wall or liver to acyclovir and its active metabolite. Its modified structure allows increased intestinal absorption and concomitant higher plasma levels of acyclovir. It demonstrates activity against HSV types 1 and 2, varicella-zoster virus, and cytomegalovirus. It exerts its effects by interfering with DNA synthesis through phosphorylation by viral thymidine kinase and subsequent inhibition of viral DNA polymerase, thereby inhibiting viral replication. Valtrex is indicated for the treatment of acute herpes zoster and recurrent genital herpes in immunocompetent adults. The most common side effects are headache, nausea, and vomiting.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
Hazardous Substances Data 124832-26-4(Hazardous Substances Data)

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