Ganciclovir , ≥98.0% , 82410-32-0

Synonym(s):
Ganciclovir;GNC;2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one;9-(1,3-Dihydroxy-2-propoxymethyl)guanine;9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine

CAS NO.：82410-32-0

Empirical Formula: C9H13N5O4

Molecular Weight: 255.23

MDL number: MFCD00870588

EINECS: 627-054-3

PRODUCT Properties

• Melting point: 250°C
• Boiling point: 398.46°C (rough estimate)
• Density: 1.3559 (rough estimate)
• refractive index: 1.7610 (estimate)
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: 0.1 M HCl: 10 mg/mL
• form: powder
• pka: 9.33±0.20(Predicted)
• color: white
• Water Solubility: 3.6g/L(25 ºC)
• Merck: 14,4363
• InChI: InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
• InChIKey: IRSCQMHQWWYFCW-UHFFFAOYSA-N
• SMILES: N1C2=C(N=C(N)NC2=O)N(COC(CO)CO)C=1

Description and Uses

Ganciclovir is a parenterally-active antiviral agent indicated for sight- or life-threatening cytomegalovirus (CMV) infections in immunocompromised patients. Its suppressive effects on bone marrow and renal tubular secretion/absorption are reported to present potential limitations on adjunct therapies involving zidovudine, vincristine, adriamycin and amphotericin B. Recently, the emergence of CMV strains resistant to ganciclovir therapy has been reported.

antiemetic

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H340-H361fd
• Precautionary statements: P201-P308+P313
• Hazard Codes: T
• Risk Statements: 46-60-61
• Safety Statements: 53-36/37/39-45
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• RTECS: MF8407000
• HS Code: 29335990
• Toxicity: LD50 i.p. in mice: 1-2 g/kg (Martin)