A0773212
Aciclovir , ≥99% , 59277-89-3
Synonym(s):
9-[(2-Hydroxyethoxy)methyl]guanine;Acycloguanosine;Acyclovir
CAS NO.:59277-89-3
Empirical Formula: C8H11N5O3
Molecular Weight: 225.2
MDL number: MFCD00057880
EINECS: 261-685-1
Pack Size | Price | Stock | Quantity |
1G | RMB24.80 | In Stock |
|
5G | RMB31.20 | In Stock |
|
25G | RMB86.40 | In Stock |
|
100G | RMB246.40 | In Stock |
|
500g | RMB828.00 | In Stock |
|
others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
Melting point: | 256-257°C |
Boiling point: | 366.71°C (rough estimate) |
Density | 1.3654 (rough estimate) |
refractive index | 1.8000 (estimate) |
storage temp. | 2-8°C |
solubility | H2O: 0.7 mg/mL |
form | powder |
pka | pKa 2.27 (Uncertain);9.25 (Uncertain) |
color | white |
Water Solubility | Soluble in 1M HCl at 50mg/ml. Soluble in water at 0.7mg/ml. Also soluble in DMSO |
Merck | 14,146 |
BCS Class | 4,3 |
Stability: | Stable. Incompatible with strong oxidizing agents. |
InChIKey | MKUXAQIIEYXACX-UHFFFAOYSA-N |
LogP | -0.617 (est) |
CAS DataBase Reference | 59277-89-3(CAS DataBase Reference) |
IARC | 3 (Vol. 76) 2000 |
Description and Uses
As it is evident from the chemical structure, acyclovir looks like a nucleoside analog of guanosine in side chain of which, instead of the traditional cyclic sugar residue a 2-hydroxyethoxymethyl acyclic side chain is present. Acyclovir possesses antiviral activity with respect to types 1 and 2 of herpes simplex, shingles virus, Epstein–Barr virus, and cytomegalovirus.
Inhibits cytomegalovirus replication; induces apoptosis
Safety
Symbol(GHS) | GHS07 |
Signal word | Warning |
Hazard statements | H320 |
Precautionary statements | P264-P305+P351+P338+P337+P313 |
Hazard Codes | Xi,Xn |
Risk Statements | 36/37/38-40-20/21/22 |
Safety Statements | 22-24/25-36-26-23 |
WGK Germany | 2 |
RTECS | UP0791400 |
HazardClass | IRRITANT |
HS Code | 29335990 |
Hazardous Substances Data | 59277-89-3(Hazardous Substances Data) |
Toxicity | LD50 in mice (mg/kg): >10,000 orally; 1000 i.p. (Schaeffer) |