Famciclovir , ≥98% , 104227-87-4

Synonym(s):
2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate ester;BRL 42810;Famciclovir

CAS NO.：104227-87-4

Empirical Formula: C14H19N5O4

Molecular Weight: 321.33

MDL number: MFCD00866964

EINECS: 630-411-6

PRODUCT Properties

• Melting point: 102-104°C
• Boiling point: 550.2±60.0 °C(Predicted)
• Density: 1.40±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: ≥10mg/mL
• form: solid
• pka: 4.00±0.10(Predicted)
• color: White to Off-White
• λmax: 310nm(EtOH)(lit.)
• InChIKey: GGXKWVWZWMLJEH-UHFFFAOYSA-N

Description and Uses

Famciclovir, an effective oral prodrug of the antiviral penciclovir, was launched in the UK and shortly after in the U.S.A. for the treatment of shingles (herpes zoster). As the diacetyl ester of the 6-deoxy- penciclovir, famciclovir has significantly improved oral absorption. It is converted to penciclovir in vivo with a bioavailability of 41 % in rats. Penciclovir is phosphorylated, and hence activated onty in herpesvirus infected cells. This stable metabolite, penciclovir-triphosphate, is a strong inhibitor of herpesvirus DNA polymerases and of viral DNA synthesis with long lasting effects. The high selectivity of famciclovir/penciclovir to herpes family of viruses and their rather low toxicity may make this agent superior to other existing drugs.

Used as an antiviral. Prodrug of Penciclovir (P221500).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P280-P305+P351+P338
• Hazard Codes: T
• Risk Statements: 20/21/22-45-61
• Safety Statements: 36/37/39-45-53-24/25
• WGK Germany: 3
• RTECS: TY3164000
• HS Code: 29335990