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A4364512

Famciclovir , ≥98% , 104227-87-4

Synonym(s):
2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate ester;BRL 42810;Famciclovir

CAS NO.:104227-87-4

Empirical Formula: C14H19N5O4

Molecular Weight: 321.33

MDL number: MFCD00866964

EINECS: 630-411-6

Pack Size Price Stock Quantity
250MG RMB23.20 In Stock
500mg RMB39.20 In Stock
1G RMB55.20 In Stock
5G RMB186.40 In Stock
25g RMB480.00 In Stock
100g RMB1432.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 102-104°C
Boiling point: 550.2±60.0 °C(Predicted)
Density  1.40±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: ≥10mg/mL
pka 4.00±0.10(Predicted)
form  solid
color  White to Off-White
λmax 310nm(EtOH)(lit.)
InChIKey GGXKWVWZWMLJEH-UHFFFAOYSA-N
CAS DataBase Reference 104227-87-4(CAS DataBase Reference)

Description and Uses

Famciclovir, an effective oral prodrug of the antiviral penciclovir, was launched in the UK and shortly after in the U.S.A. for the treatment of shingles (herpes zoster). As the diacetyl ester of the 6-deoxy- penciclovir, famciclovir has significantly improved oral absorption. It is converted to penciclovir in vivo with a bioavailability of 41 % in rats. Penciclovir is phosphorylated, and hence activated onty in herpesvirus infected cells. This stable metabolite, penciclovir-triphosphate, is a strong inhibitor of herpesvirus DNA polymerases and of viral DNA synthesis with long lasting effects. The high selectivity of famciclovir/penciclovir to herpes family of viruses and their rather low toxicity may make this agent superior to other existing drugs.

Used as an antiviral. Prodrug of Penciclovir (P221500).

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  T
Risk Statements  20/21/22-45-61
Safety Statements  36/37/39-45-53-24/25
WGK Germany  3
RTECS  TY3164000
HS Code  29335990
Hazardous Substances Data 104227-87-4(Hazardous Substances Data)

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