Valacyclovir Hydrochloride Hydrate , ≥98%(HPLC) , 124832-27-5

Synonym(s):
2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester monohydrochloride;L-Valine;Valacyclovir hydrochloride;Valtrex

CAS NO.：124832-27-5

Empirical Formula: C13H21ClN6O4

Molecular Weight: 360.8

MDL number: MFCD01861507

EINECS: 641-092-8

PRODUCT Properties

• Melting point: 170-172°C
• storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• solubility: H2O: >20mg/mL
• form: solid
• color: white
• λmax: 253nm(H2O)(lit.)
• Merck: 14,9899
• Stability: Hygroscopic
• CAS DataBase Reference: 124832-27-5(CAS DataBase Reference)

Description and Uses

Valacyclovir hydrochloride, an orally active L-valyl ester of the potent antiviral agent aciclovir, was launched in 1995 in the United Kingdom for the treatment of herpes simplex virus (HSV) infections of the skin and mucous membranes, including initial and recurrent genital herpes. As a prodrug, valaciclovir has an improved pharmacokinetic profile to aciclovir. It is rapidly absorbed after oral administration and extensively converted to aciclovir via first-pass metabolism to achieve plasma levels of aciclovir comparable to those seen with aciclovir via i.v. route. Valacyclovir is then activated selectively in virus-infected cells by viral thymidine kinase to form aciclovir triphosphate in a stepwise fashion. This active species inhibits viral DNA polymerase via irreversible binding to the active site of the enzyme. Once aciclovir is incorporated into the elongating viral DNA, it terminates replication of the viral DNA strand, an antiviral mechanism unique to aciclovir. Valacyclovir is reportedly in clinical trials for the suppression of cytomegalovirus infection and disease in renal transplant patients.

Valaciclovir hydrochloride is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-22
• Safety Statements: 26-36-24/25
• RIDADR: 3077
• WGK Germany: 3
• HS Code: 29335990