PRODUCT Properties
| Melting point: | 89-96°C |
| alpha | D20 -50° (c = 2 in CHCl3) |
| Boiling point: | 578.63°C (rough estimate) |
| Density | 1.1174 (rough estimate) |
| refractive index | 1.5800 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Soluble in Water (100 mg/ml) |
| form | solid |
| pka | 5.77, 6.64(at 25℃) |
| color | White |
| Water Solubility | 961.3mg/L(15 ºC) |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 3 months. |
Description and Uses
Emetine hydrochloride (483-18-1) is one of the active ingredients of ipecac root extract, used as an emetic.1 Induces apoptosis in breast cancer cells via inhibition of Wnt/β-catenin signaling.2 Inhibits Zika and Ebola virus in vitro and in vivo, targeting viral entry and replication by inhibiting viral RNA polymerase and host lysosomal function.3 Also inhibits SARS-CoV-2 replication in cells (EC50 for viral load reduction is 0.46 μM).4 A useful agent for inhibiting protein synthesis in eukaryotic cells by virtue of its inhibition of the ribosome 40S subunit.5
Emetine is the principal alkaloid of ipecac, the ground roots of Uragoga ipecacuanha.
Safety
| RIDADR | 1544 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 i.p. in rats: 12.1 mg/kg (Radomski) |
