Ivermectine , Analysis standard , 70288-86-7

Synonym(s):
22,23-Dihydroavermectin B1;Ivermectin;MK-933

CAS NO.：70288-86-7

Empirical Formula: C48H74O14

Molecular Weight: 875.09

MDL number: MFCD00869511

EINECS: 274-536-0

PRODUCT Properties

• alpha: D +71.5 ± 3° (c = 0.755 in chloroform)
• RTECS: IH7891500
• storage temp.: 2-8°C
• solubility: H₂O: ≤1.0% KF
• form: powder
• color: White
• Water Solubility: 4mg/L(temperature not stated)
• BCS Class: 4/3
• Stability: Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
• InChIKey: AZSNMRSAGSSBNP-XPNPUAGNSA-N

Description and Uses

Ivermectin is an antiparasitic agent effective in the treatment of onchocerciasis, or "river blindness". Since ivermectin acts to prevent the adult worm from producing microfilariae, it needs to be administered only once or twice a year.

Semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Anthelmintic (Onchocerca).

Safety

• Symbol(GHS): GHS06,GHS09
• Signal word: Danger
• Hazard statements: H300-H311-H410
• Precautionary statements: P264-P270-P273-P280-P301+P310-P302+P352+P312
• Hazard Codes: T,Xn,T+
• Risk Statements: 61-25-36-36/38-22-28
• Safety Statements: 53-26-45-36-36/37-28
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• HazardClass: 6.1(a)
• PackingGroup: II
• HS Code: 29322090
• Toxicity: LD50 in dogs, rhesus monkeys (mg/kg): about 80, more than 24 orally. (MSDS Merck & Co. Inc., 2003)