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A7089258

Droperidol , 10mMinDMSO , 548-73-2

Synonym(s):
1-[1-[3-(p-Fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone;Droperidol

CAS NO.:548-73-2

Empirical Formula: C22H22FN3O2

Molecular Weight: 379.43

MDL number: MFCD00083290

EINECS: 208-957-8

Pack Size Price Stock Quantity
1ml RMB559.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 148-149°C
Density  1.2154 (estimate)
storage temp.  2-8°C
solubility  Practically insoluble in water, freely soluble in dimethylformamide and in methylene chloride, sparingly soluble in ethanol (96 per cent).
form  Solid
pka 7.64(at 25℃)
color  Pale Yellow to Pale Beige
Water Solubility  4.1mg/L(30 ºC)

Description and Uses

D roperidol is a butyrophenone that has potent antidopaminergic (D2) activity and mild α2-blocking actions. It produces sedation and anxiolysis and is an effective antiemetic. A dverse effects include vasodilatation and hypotension, and at higher doses, dystonic reactions can occur. D roperidol was used for premedication and in neuroleptanaesthesia until reports of death from long QT syndrome led to its withdrawal in 2001. It has recently been reintroduced and licenced at lower doses for prevention of postoperative nausea and vomiting. D roperidol has an onset of 3–10 min after i.v. injection and duration of action of 6–12h. It undergoes hepatic metabolism, but approximately 10% of the drug is excreted unchanged in the urine.

A D1DR and D2DR inhibitor.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
RIDADR  3249
WGK Germany  3
RTECS  DE2100000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933995800
Toxicity LD50 oral in rat: 750mg/kg

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