Saracatinib(AZD0530) , 98% , 379231-04-6

CAS NO.：379231-04-6

Empirical Formula: C27H32ClN5O5

Molecular Weight: 542.03

MDL number: MFCD09832698

EINECS: 1592732-453-0

PRODUCT Properties

• Melting point: 84-89°C
• Boiling point: 671.2±55.0 °C(Predicted)
• Density: 1.348
• storage temp.: -20°C
• solubility: Soluble in DMSO (50 mg/ml) and ethanol (54 mg/mL with warming)
• form: solid
• pka: 7.55±0.10(Predicted)
• color: White
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Description and Uses

Saracatinib is a dual inhibitor of the tyrosine kinases c-Src and Abl (IC₅₀ = 2.7 and 30 nM, respectively). It less effectively inhibits other receptor and non-receptor tyrosine kinases as well as assorted serine/threonine kinases. Saracatinib is orally available and blocks cell motility, migration, adhesion, invasion, proliferation, differentiation, and survival. Through its effects on c-Src, it reduces osteoclast bone resorption. Saracatinib also blocks denque virus RNA replication through its effect on Fyn kinase.

An oral, selective dual inhibitor of Src and ABL kinase. It is a COVID19-related research product.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H317-H319
• Precautionary statements: P280-P305+P351+P338