3-Aminobenzamide , 98% , 3544-24-9

Synonym(s):
3-AB;3-ABA;3-Aminobenzamide;PARP Inhibitor I, 3-ABA - CAS 3544-24-9 - Calbiochem

CAS NO.：3544-24-9

Empirical Formula: C7H8N2O

Molecular Weight: 136.15

MDL number: MFCD00007989

EINECS: 222-586-9

PRODUCT Properties

• Melting point: 115-116 °C (lit.)
• Boiling point: 250.42°C (rough estimate)
• Density: 1.1778 (rough estimate)
• refractive index: 1.5769 (estimate)
• storage temp.: room temp
• solubility: ethanol: 50 mg/mL, clear, faintly yellow
• form: powder
• pka: 16.26±0.50(Predicted)
• color: white to off-white
• Water Solubility: Soluble in dimethylformamide (~30 mg/ml), dimethyl sulfoxide (~30 mg/ml), phosphate buffered saline (pH7.2) (~2 mg/ml), water (25 mg/ml), and ethanol (25 mg/ml).
• Sensitive: Light Sensitive
• BRN: 2802373
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
• LogP: -0.330

Description and Uses

The poly(ADP-ribose) polymerases (PARPs) comprise a family of enzymes which post-translationally modify proteins by poly(ADP-ribosyl)ation. Since some PARPs are activated by DNA strand breaks, PARP signaling has roles in DNA repair, apoptosis, inflammation, and other cellular responses. 3-amino Benzamide is an inhibitor of PARPs (K_i = 1.8 μM). Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.

The poly(ADP-ribose) polymerases (PARPs) comprise a family of enzymes which post-translationally modify proteins by poly(ADP-ribosyl)ation. Since some PARPs are activated by DNA strand breaks, PARP signaling has roles in DNA repair, apoptosis, inflammation, and other cellular responses. 3-amino Benzamide is an inhibitor of PARPs (Ki = 1.8 μM). Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P280-P301+P312+P330-P304+P340+P312-P305+P351+P338-P337+P313-P261-P280a-P304+P340-P405-P501a-P264-P270-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36-37/39
• RIDADR: 3077
• WGK Germany: 3
• RTECS: CU8992000
• HS Code: 29242990