Olaparib (AZD2281, Ku-0059436) , ≥98% , 763113-22-0
CAS NO.：763113-22-0
Empirical Formula: C24H23FN4O3
Molecular Weight: 434.46
MDL number: MFCD13185161
EINECS: 642-941-5
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB39.20 | In Stock |
|
| 25MG | RMB79.20 | In Stock |
|
| 100MG | RMB155.20 | In Stock |
|
| 250MG | RMB221.60 | In Stock |
|
| 1G | RMB604.80 | In Stock |
|
| 5G | RMB1368.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Density | 1.43 |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 33 mg/ml) or in Ethanol (up to 1.7 mg/ml) |
| pka | 12.07±0.40(Predicted) |
| form | solid |
| color | Off-white |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| InChIKey | FDLYAMZZIXQODN-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=CC=C2)C(CC2=CC=C(F)C(C(N3CCN(C(C4CC4)=O)CC3)=O)=C2)=NN1 |
Description and Uses
Olaparib, marketed by AstraZeneca under the brand name Lynparza , was approved in the USA in December 2014 as a targeted, single-agent therapy for the treatment of germline BRCA-mediated advanced ovarian cancer.Olaparib, originally developed by KuDOS pharmaceuticals and later by AstraZeneca, functions as a poly ADP ribose polymerase inhibitor and has been specifically approved for patients who have received three or more treatments of chemotherapy. In clinical trials, the drug prolonged progression- free survival for patients suffering from platinum-sensitive recurrent serous ovarian cancer. Olaparib is also currently in various phases of investigation for treatment of breast, gastric, prostate, pancreatic and non-small cell lung cancer.
Olaparib is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib has been shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy.
Safety
| Symbol(GHS) |  GHS05 |
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P501-P260-P264-P280-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P405 |
| Risk Statements | 22-38-37-36 |
| Safety Statements | 24/25-37/39 |
| HazardClass | IRRITANT |
| HS Code | 29339900 |
