Olaparib (AZD2281, Ku-0059436) , ≥98% , 763113-22-0

CAS NO.：763113-22-0

Empirical Formula: C24H23FN4O3

Molecular Weight: 434.46

MDL number: MFCD13185161

EINECS: 642-941-5

PRODUCT Properties

• Density: 1.43
• storage temp.: -20°C
• solubility: Soluble in DMSO (up to 33 mg/ml) or in Ethanol (up to 1.7 mg/ml)
• pka: 12.07±0.40(Predicted)
• form: solid
• color: Off-white
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
• InChIKey: FDLYAMZZIXQODN-UHFFFAOYSA-N
• SMILES: C1(=O)C2=C(C=CC=C2)C(CC2=CC=C(F)C(C(N3CCN(C(C4CC4)=O)CC3)=O)=C2)=NN1
• CAS DataBase Reference: 763113-22-0

Description and Uses

Olaparib, marketed by AstraZeneca under the brand name Lynparza , was approved in the USA in December 2014 as a targeted, single-agent therapy for the treatment of germline BRCA-mediated advanced ovarian cancer.Olaparib, originally developed by KuDOS pharmaceuticals and later by AstraZeneca, functions as a poly ADP ribose polymerase inhibitor and has been specifically approved for patients who have received three or more treatments of chemotherapy. In clinical trials, the drug prolonged progression- free survival for patients suffering from platinum-sensitive recurrent serous ovarian cancer. Olaparib is also currently in various phases of investigation for treatment of breast, gastric, prostate, pancreatic and non-small cell lung cancer.

Olaparib is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib has been shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy.

Safety

• Symbol(GHS): GHS05
• Signal word: Danger
• Hazard statements: H314
• Precautionary statements: P501-P260-P264-P280-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P405
• Risk Statements: 22-38-37-36
• Safety Statements: 24/25-37/39
• HazardClass: IRRITANT
• HS Code: 29339900