calcitriol , 97% , 32222-06-3
Synonym(s):
Calcitriol;(1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol monohydrate;1α,25-Dihydroxycholecalciferol;1α,25-Dihydroxycholecalciferol monohydrate;1α,25-Dihydroxyvitamin D3
CAS NO.：32222-06-3
Empirical Formula: C27H44O3
Molecular Weight: 416.64
MDL number: MFCD00867079
EINECS: 250-963-8
| Pack Size | Price | Stock | Quantity |
| 1MG | RMB332.00 | In Stock |
|
| 5MG | RMB988.00 | In Stock |
|
| 25MG | RMB1748.00 | In Stock |
|
| 100mg | RMB3519.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 119-1210C |
| alpha | D25 +48° (methanol) |
| Boiling point: | 474.91°C (rough estimate) |
| Density | 1.0362 (rough estimate) |
| refractive index | 1.4700 (estimate) |
| Flash point: | 14 °C |
| storage temp. | 2-8°C |
| pka | 14.43±0.40(Predicted) |
| form | Solid |
| color | White to Almost white |
| λmax | 265nm(lit.) |
| Merck | 14,1644 |
| BRN | 7559394 |
| BCS Class | 2,4 |
| Stability: | Air and Light Sensitive |
| InChIKey | GMRQFYUYWCNGIN-UNVJKIGWSA-N |
| CAS DataBase Reference | 32222-06-3(CAS DataBase Reference) |
Description and Uses
Calcitriol is the active form of vitamin D and is also a kind of hormones in the body. It plays an important role in the regulation of calcium and phosphorus concentration. It can increase the blood calcium level by increasing the intestinal absorption of calcium and can also increase the release of the bone calcium release for increasing the blood calcium levels. Plasma levels of calcitriol range from 10-70 pg/ml. Clinically, this drug can be used in the treatment of hypocalcemia, hypoparathyroidism (adult), osteomalacia, rickets (infants), chronic kidney disease, renal osteodystrophy, osteoporosis, as well as the prevention of glucocorticoid induced osteoporosis.
Calcitriol-dimensional molecular structure
The above information is edited by the chemicalbook of Dai Xiongfeng.
Calcitriol is the biologically active form of vitamin D3, and its primary physiological effects are to increase calcium absorption by intestinal epithelial cells and increase bone mineralization by directly stimulating osteoblasts. It is therefore also used as a calcium regulator to treat symptoms of low calcium levels caused by kidney disease. It can also treat parathyroid disease. Calcitriol can regulate parathyroid levels by increasing the amount of calcium (vitamin D) in the body.
Safety
| Symbol(GHS) |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H300+H310+H330-H372 |
| Precautionary statements | P260-P262-P280-P302+P352+P310-P304+P340+P310-P314 |
| Hazard Codes | T+,Xn,F |
| Risk Statements | 26/27/28-63-36/37/38-20/21/22-11 |
| Safety Statements | 36/37/39-45-36-26-16-7 |
| RIDADR | UN 2811 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | FZ4645000 |
| F | 8-10-19 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| HS Code | 29061900 |
| Hazardous Substances Data | 32222-06-3(Hazardous Substances Data) |
| Toxicity | mouse,LD50,intraperitoneal,1900ug/kg (1.9mg/kg),SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYEBEHAVIORAL: ATAXIA,Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 11, Pg. 4175, 1983. |
