Ambroxol HCl , ≥99% , 23828-92-4

Synonym(s):
2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine;Ambroxol hydrochloride

CAS NO.：23828-92-4

Empirical Formula: C13H19Br2ClN2O

Molecular Weight: 414.56

MDL number: MFCD00078932

EINECS: 245-899-2

PRODUCT Properties

• Melting point: 233-234.5°C
• storage temp.: Inert atmosphere,2-8°C
• solubility: Sparingly soluble in water, soluble in methanol, practically insoluble in methylene chloride.
• form: Solid
• color: White to Off-White
• PH: pH(10g/l, 25℃) : 4.0～6.0
• Water Solubility: Slightly soluble in water (~5 mg/ml) or ethanol (~5 mg/ml).
• Merck: 14,386
• InChI: InChI=1/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H/t10-,11-
• InChIKey: QNVKOSLOVOTXKF-PFWPSKEQSA-N
• SMILES: [C@@H]1(O)CC[C@@H](NCC2=CC(Br)=CC(Br)=C2N)CC1.[H]Cl |&1:0,4,r|
• CAS DataBase Reference: 23828-92-4(CAS DataBase Reference)

Description and Uses

Ambroxol hydrochloride is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy. Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion. It enhances pulmonary surfactant production and stimulates ciliary activity.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 36
• WGK Germany: 3
• RTECS: GV8423000
• HS Code: 29221980
• Toxicity: LD50 in mice, rats (mg/kg): 268, 380 i.p.; 2720, 13400 orally (Püschmann, Engelhorn)