Olopatadine Hydrochloride , >98.0%(HPLC) , 140462-76-6

Synonym(s):
(11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride;AL-4943A;KW-4679;Opatanol;Patanol

CAS NO.：140462-76-6

Empirical Formula: C21H24ClNO3

Molecular Weight: 373.873

MDL number: MFCD00875716

EINECS: 604-185-4

PRODUCT Properties

• Melting point: 242-245?C
• storage temp.: Inert atmosphere,Room Temperature
• solubility: H2O: ≥20mg/mL
• form: solid
• color: White to Light yellow
• Merck: 14,6840
• BCS Class: 3(CLogP), 1 (LogP)
• InChI: InChI=1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-
• InChIKey: HVRLZEKDTUEKQH-NOILCQHBSA-N
• SMILES: C(=C1/C2=CC=CC=C2COC2C=CC(CC(=O)O)=CC/1=2)\CCN(C)C.Cl

Description and Uses

Olopatadine hydrochloride is an ophthalmic antihistamine that inhibits release of histamine from mast cells and is a relatively selective histamine H1 antagonist. It inhibits type 1 immediate hypersensitivity reactions. Olopatadine hydrochloride is indicated in the temporary relief of itching caused by allergic conjunctivitis. H1 antagonists have an established and valued place in the symptomatic treatment of various immediate hypersensitivity reactions. In addition, the central properties of some of the series are of therapeutic value for suppressing motion sickness or for sedation.

Dual acting histamine H1-receptor antagonist and mast cell stabilizer. Antiallergic; antihistaminic.

Safety

• Symbol(GHS): GHS06,GHS09
• Signal word: Danger
• Hazard statements: H301-H400
• Precautionary statements: P273-P301+P310+P330
• Hazard Codes: T,N
• Risk Statements: 25-50
• Safety Statements: 45-61
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• RTECS: HQ4135060
• HS Code: 29329990