Doxorubicin hydrochloride , 98% , 25316-40-9

Synonym(s):
DOX;Doxorubicin hydrochloride;Adriamycin;Adriamycin, HCl, 14-Hydroxydaunomycin, HCl;Hydroxydaunorubicin hydrochloride

CAS NO.：25316-40-9

Empirical Formula: C27H30ClNO11

Molecular Weight: 579.98

MDL number: MFCD00077757

EINECS: 246-818-3

PRODUCT Properties

• Melting point: 216 °C (dec.)(lit.)
• alpha: D20 +248±2° (c = 0.1 in methanol)
• storage temp.: 2-8°C
• solubility: Soluble in DMSO at 100 mg/ml; very poorly soluble in ethanol; soluble in water at 10 mg/ml with slight warming.
• pka: pKa 8.25±0.60 (Uncertain);8.43±0.70 (Uncertain);11.9±0.4 (Uncertain);12.95±0.1 (Uncertain);13.8±0.70 (Uncertain)
• form: solid
• color: orange to dark red
• Water Solubility: Soluble in water.
• λmax: 497nm(H2O)(lit.)
• Merck: 14,3439
• BRN: 4229251
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
• InChIKey: MWWSFMDVAYGXBV-RUELKSSGSA-N

Description and Uses

Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.[Cayman Chemical]

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302-H340-H350-H360FD
• Precautionary statements: P201-P202-P264-P270-P301+P312-P308+P313
• Hazard Codes: T,T+,Xi
• Risk Statements: 45-22-40-26/27/28-36/38
• Safety Statements: 53-45-36/37/39-22-7/9
• WGK Germany: 3
• RTECS: QI9295900
• F: 10-21
• HS Code: 29419090
• Toxicity: LD50 i.v. in mice: 21.1 mg/kg (Bertazzoli, 1970)