A0427456
Doxorubicinhydrochloride , 97% , 25316-40-9
Synonym(s):
DOX;Doxorubicin hydrochloride;Adriamycin;Adriamycin, HCl, 14-Hydroxydaunomycin, HCl;Hydroxydaunorubicin hydrochloride
CAS NO.:25316-40-9
Empirical Formula: C27H30ClNO11
Molecular Weight: 579.98
MDL number: MFCD00077757
EINECS: 246-818-3
Pack Size | Price | Stock | Quantity |
100mg | RMB127.20 | In Stock |
|
25mg | RMB399.20 | In Stock |
|
500mg | RMB495.20 | In Stock |
|
others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
Melting point: | 216 °C (dec.)(lit.) |
alpha | D20 +248±2° (c = 0.1 in methanol) |
storage temp. | 2-8°C |
solubility | Soluble in DMSO at 100 mg/ml; very poorly soluble in ethanol; soluble in water at 10 mg/ml with slight warming. |
pka | pKa 8.25±0.60 (Uncertain);8.43±0.70 (Uncertain);11.9±0.4 (Uncertain);12.95±0.1 (Uncertain);13.8±0.70 (Uncertain) |
form | solid |
color | orange to dark red |
Water Solubility | Soluble in water. |
λmax | 497nm(H2O)(lit.) |
Merck | 14,3439 |
BRN | 4229251 |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months. |
InChIKey | MWWSFMDVAYGXBV-RUELKSSGSA-N |
CAS DataBase Reference | 25316-40-9(CAS DataBase Reference) |
EPA Substance Registry System | Doxorubicin hydrochloride (25316-40-9) |
Description and Uses
Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.[Cayman Chemical]
Safety
Symbol(GHS) | GHS07,GHS08 |
Signal word | Danger |
Hazard statements | H302-H340-H350-H360FD |
Precautionary statements | P201-P202-P264-P270-P301+P312-P308+P313 |
Hazard Codes | T,T+,Xi |
Risk Statements | 45-22-40-26/27/28-36/38 |
Safety Statements | 53-45-36/37/39-22-7/9 |
WGK Germany | 3 |
RTECS | QI9295900 |
F | 10-21 |
HS Code | 29419090 |
Toxicity | LD50 i.v. in mice: 21.1 mg/kg (Bertazzoli, 1970) |