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A0660257

Gestrinone , ≥99% , 16320-04-0

CAS NO.:16320-04-0

Empirical Formula: C21H24O2

Molecular Weight: 308.41

MDL number: MFCD00865561

EINECS: 685-143-2

Pack Size Price Stock Quantity
25mg RMB239.20 In Stock
100mg RMB799.20 In Stock
500mg RMB3199.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 150-152°C
alpha  D20 +84.6° (c = 0.41 in methanol)
Boiling point: 388.8°C (rough estimate)
Density  1.1040 (rough estimate)
refractive index  1.4900 (estimate)
storage temp.  -20°C Freezer
solubility  DMF:20.0(Max Conc. mg/mL);64.85(Max Conc. mM)
DMSO:35.0(Max Conc. mg/mL);113.48(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);64.85(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:5):0.25(Max Conc. mg/mL);81.06(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);3.24(Max Conc. mM)
form  A crystalline solid
pka 12.76±0.40(Predicted)
color  Off-white to light yellow
Merck  14,4415
Stability: Hygroscopic
InChI InChI=1S/C21H24O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,9,11,13,18-19,23H,3,5-8,10,12H2,1H3/t18-,19+,20+,21+/m1/s1
InChIKey BJJXHLWLUDYTGC-ANULTFPQSA-N
SMILES C1C2C(CC[C@]3([H])C=2C=C[C@@]2(CC)[C@@]3([H])CC[C@]2(C#C)O)=CC(=O)C1
CAS DataBase Reference 16320-04-0(CAS DataBase Reference)

Description and Uses

Gestrinone is a synthetic steroid with antiprogesterone and antiestrogenic activities. It is reported to be useful in the treatment of endometriosis and uterine leiom yomas.

Steroidal antiestrogen, antiprogestogen, analog of Norgestrienone. Antigonadotropin. Controlled substance.

Safety

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H360-H362
Precautionary statements  P201-P260-P263-P264-P270-P308+P313
RTECS  JF7964000
Toxicity mouse,LDLo,intraperitoneal,1gm/kg (1000mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)GASTROINTESTINAL: OTHER CHANGES,Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 701, 1988.

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