A0660257
Gestrinone , ≥99% , 16320-04-0
CAS NO.:16320-04-0
Empirical Formula: C21H24O2
Molecular Weight: 308.41
MDL number: MFCD00865561
EINECS: 685-143-2
Pack Size | Price | Stock | Quantity |
25mg | RMB239.20 | In Stock |
|
100mg | RMB799.20 | In Stock |
|
500mg | RMB3199.20 | In Stock |
|
others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
Melting point: | 150-152°C |
alpha | D20 +84.6° (c = 0.41 in methanol) |
Boiling point: | 388.8°C (rough estimate) |
Density | 1.1040 (rough estimate) |
refractive index | 1.4900 (estimate) |
storage temp. | -20°C Freezer |
solubility | DMF:20.0(Max Conc. mg/mL);64.85(Max Conc. mM) DMSO:35.0(Max Conc. mg/mL);113.48(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);64.85(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:5):0.25(Max Conc. mg/mL);81.06(Max Conc. mM) Water:1.0(Max Conc. mg/mL);3.24(Max Conc. mM) |
form | A crystalline solid |
pka | 12.76±0.40(Predicted) |
color | Off-white to light yellow |
Merck | 14,4415 |
Stability: | Hygroscopic |
InChI | InChI=1S/C21H24O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,9,11,13,18-19,23H,3,5-8,10,12H2,1H3/t18-,19+,20+,21+/m1/s1 |
InChIKey | BJJXHLWLUDYTGC-ANULTFPQSA-N |
SMILES | C1C2C(CC[C@]3([H])C=2C=C[C@@]2(CC)[C@@]3([H])CC[C@]2(C#C)O)=CC(=O)C1 |
CAS DataBase Reference | 16320-04-0(CAS DataBase Reference) |
Description and Uses
Gestrinone is a synthetic steroid with antiprogesterone and antiestrogenic activities. It is reported to be useful in the treatment of endometriosis and uterine leiom yomas.
Steroidal antiestrogen, antiprogestogen, analog of Norgestrienone. Antigonadotropin. Controlled substance.
Safety
Symbol(GHS) | GHS08 |
Signal word | Danger |
Hazard statements | H360-H362 |
Precautionary statements | P201-P260-P263-P264-P270-P308+P313 |
RTECS | JF7964000 |
Toxicity | mouse,LDLo,intraperitoneal,1gm/kg (1000mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)GASTROINTESTINAL: OTHER CHANGES,Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 701, 1988. |