Home Categories API Progesterone
A6663612

Progesterone , USP level , 57-83-0

Synonym(s):
Lutein;Progesterone;Xanthophyll;4-Pregnene-3,20-dione;Progesterone - CAS 57-83-0 - Calbiochem

CAS NO.:57-83-0

Empirical Formula: C21H30O2

Molecular Weight: 314.46

MDL number: MFCD00003658

EINECS: 200-350-6

Pack Size Price Stock Quantity
25G RMB398.40 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: 128-132 °C (lit.)
alpha  186 º (c=1, ethanol)
Boiling point: 394.13°C (rough estimate)
Density  d23 1.166; d20 1.171
refractive index  182 ° (C=2, Dioxane)
Flash point: 2℃
storage temp.  room temp
solubility  H2O: 25 mg/mL, may be clear to slightly hazy
form  powder
color  Yellow to yellow-brown
Water Solubility  <0.1 g/100 mL at 19 ºC
Merck  7773
BRN  1915950
BCS Class 4
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey RJKFOVLPORLFTN-LEKSSAKUSA-N
LogP 3.870

Description and Uses

Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells. Progesterone activates the human progesterone receptor with an EC50 value of 0.5 nM.

Steroid hormone produced by the corpus luteum. Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.This compound is a contaminant of emerging concern (CECs).

Safety

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H351-H360FD-H362
Precautionary statements  P202-P260-P263-P264-P270-P308+P313
Hazard Codes  Xn,T,F
Risk Statements  40-45-62-36-20/21/22-11
Safety Statements  36/37-45-53-16
RIDADR  UN 1648 3 / PGII
WGK Germany  3
RTECS  TW0175000
HS Code  29372390
Toxicity LD50 intraperitoneal in rat: 327mg/kg

RELATED PRODUCTS