Progesterone , USP level , 57-83-0

Synonym(s):
Lutein;Progesterone;Xanthophyll;4-Pregnene-3,20-dione;Progesterone - CAS 57-83-0 - Calbiochem

CAS NO.：57-83-0

Empirical Formula: C21H30O2

Molecular Weight: 314.46

MDL number: MFCD00003658

EINECS: 200-350-6

PRODUCT Properties

• Melting point: 128-132 °C (lit.)
• alpha: 186 º (c=1, ethanol)
• Boiling point: 394.13°C (rough estimate)
• Density: d23 1.166; d20 1.171
• refractive index: 182 ° (C=2, Dioxane)
• Flash point: 2℃
• storage temp.: room temp
• solubility: H₂O: 25 mg/mL, may be clear to slightly hazy
• form: powder
• color: Yellow to yellow-brown
• Water Solubility: <0.1 g/100 mL at 19 ºC
• Merck: 7773
• BRN: 1915950
• BCS Class: 4
• Stability: Stable. Incompatible with strong oxidizing agents.
• InChIKey: RJKFOVLPORLFTN-LEKSSAKUSA-N
• LogP: 3.870

Description and Uses

Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ^4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells. Progesterone activates the human progesterone receptor with an EC₅₀ value of 0.5 nM.

Steroid hormone produced by the corpus luteum. Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.This compound is a contaminant of emerging concern (CECs).

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H351-H360FD-H362
• Precautionary statements: P202-P260-P263-P264-P270-P308+P313
• Hazard Codes: Xn,T,F
• Risk Statements: 40-45-62-36-20/21/22-11
• Safety Statements: 36/37-45-53-16
• RIDADR: UN 1648 3 / PGII
• WGK Germany: 3
• RTECS: TW0175000
• HS Code: 29372390
• Toxicity: LD50 intraperitoneal in rat: 327mg/kg