Pregnenolone , ≥98%(GC) , 145-13-1

Synonym(s):
3β-Hydroxy-5-pregnen-20-one;3β-hydroxypregn-5-en-20-one;Pregnenolone

CAS NO.：145-13-1

Empirical Formula: C21H32O2

Molecular Weight: 316.48

MDL number: MFCD00003628

EINECS: 205-647-4

PRODUCT Properties

• Melting point: 188-190 °C
• alpha: 28.5 º (c=1, EtOH)
• Boiling point: 395.89°C (rough estimate)
• Density: 1.0382 (rough estimate)
• vapor pressure: 0-0Pa at 20-25℃
• refractive index: 1.5344 (estimate)
• Flash point: 9℃
• storage temp.: Refrigerator
• solubility: ethanol: soluble10mg/mL, clear, colorless to faintly yellow
• form: Powder
• pka: 15.00±0.70(Predicted)
• color: White to off-white
• Water Solubility: 41mg/L(room temperature)
• Merck: 7733
• BRN: 2059026
• InChIKey: ORNBQBCIOKFOEO-QGVNFLHTSA-N
• LogP: 4.4 at 20℃

Description and Uses

Pregnenolone serves as the common precursor in the formation of the adrenocorticoids and other steroid hormones. This C21 steroid is converted via enzymatic oxidations and isomerization of the double bond to a number of physiologically active C21 steroids, including the female sex hormone progesterone and the adrenocorticoids hydrocortisone (cortisol), corticosterone, and aldosterone. Oxidative cleavage of the two-carbon side chain of pregnenolone and subsequent enzymatic oxidations and isomerization lead to C19 steroids, including the androgens testosterone and dihydrotestosterone. The final group of steroids, the C18 female sex hormones, are derived from oxidative aromatization of the A ring of androgens to produce estrogens.

glucocortcoid, antiinflammatory

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H225-H302+H312+H332-H319
• Precautionary statements: P210-P280-P305+P351+P338
• Safety Statements: 22-24/25
• RIDADR: UN 1648 3 / PGII
• WGK Germany: 3
• RTECS: TU5560700
• HS Code: 29372900