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A6663512

Progesterone , 98% , 57-83-0

Synonym(s):
Lutein;Progesterone;Xanthophyll;4-Pregnene-3,20-dione;Progesterone - CAS 57-83-0 - Calbiochem

CAS NO.:57-83-0

Empirical Formula: C21H30O2

Molecular Weight: 314.46

MDL number: MFCD00003658

EINECS: 200-350-6

Pack Size Price Stock Quantity
1g RMB41.60 In Stock
5G RMB74.40 In Stock
25G RMB180.80 In Stock
100G RMB616.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 128-132 °C (lit.)
Boiling point: 394.13°C (rough estimate)
alpha  186 º (c=1, ethanol)
Density  d23 1.166; d20 1.171
refractive index  182 ° (C=2, Dioxane)
Flash point: 2℃
storage temp.  room temp
solubility  H2O: 25 mg/mL, may be clear to slightly hazy
form  powder
color  Yellow to yellow-brown
Water Solubility  <0.1 g/100 mL at 19 ºC
Merck  7773
BRN  1915950
BCS Class 4
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey RJKFOVLPORLFTN-LEKSSAKUSA-N
LogP 3.870
CAS DataBase Reference 57-83-0(CAS DataBase Reference)
NIST Chemistry Reference Progesterone(57-83-0)
EPA Substance Registry System Progesterone (57-83-0)

Description and Uses

Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells. Progesterone activates the human progesterone receptor with an EC50 value of 0.5 nM.

Steroid hormone produced by the corpus luteum. Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.This compound is a contaminant of emerging concern (CECs).

Safety

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H351-H360FD-H362
Precautionary statements  P202-P260-P263-P264-P270-P308+P313
Hazard Codes  Xn,T,F
Risk Statements  40-45-62-36-20/21/22-11
Safety Statements  36/37-45-53-16
RIDADR  UN 1648 3 / PGII
WGK Germany  3
RTECS  TW0175000
HS Code  29372390
Hazardous Substances Data 57-83-0(Hazardous Substances Data)
Toxicity LD50 intraperitoneal in rat: 327mg/kg

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