Mifepristone , ≥98% , 84371-65-3

Synonym(s):
(11β,17β)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one, RU-486;11β-(4-Dimethyl-amino)-phenyl-17β-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one;Mifepristone - CAS 84371-65-3 - Calbiochem;RU-38486;RU-486

CAS NO.：84371-65-3

Empirical Formula: C29H35NO2

Molecular Weight: 429.6

MDL number: MFCD00867226

EINECS: 617-559-7

PRODUCT Properties

• Melting point: 195-198°C
• alpha: D20 +138.5° (c = 0.5 in chloroform)
• Boiling point: 544.13°C (rough estimate)
• Density: 1.0731 (rough estimate)
• refractive index: 1.6290 (estimate)
• storage temp.: 2-8°C
• solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).
• form: Yellow solid
• pka: 12.94±0.60(Predicted)
• color: Yellow
• Water Solubility: 474.8ug/L(22.5 ºC)
• Merck: 14,6186
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
• InChIKey: VKHAHZOOUSRJNA-GCNJZUOMSA-N
• CAS DataBase Reference: 84371-65-3(CAS DataBase Reference)

Description and Uses

Mifepristone is an orally-active progesterone and glucocorticoid receptor antagonist indicated for use as a post-coital contraceptive. In addition to being an abortifacient, mifepristone is reported to be effective in the treatment of ocular hypertension; its potential therapeutic effect in hormone-dependent tumors is currently under investigation.

A progesterone and glucocorticoid antagonist, suppresses VEGF production.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H360
• Precautionary statements: P201-P308+P313
• Hazard Codes: T
• Risk Statements: 60-61
• Safety Statements: 53-22-36/37/39-45
• WGK Germany: 3
• RTECS: KG2955000
• HS Code: 29372900
• Hazardous Substances Data: 84371-65-3(Hazardous Substances Data)