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A7642558

Misoprostol , 10mMinDMSO , 59122-46-2

Synonym(s):
(±)-15-Deoxy-(16RS)-16-hydroxy-16-methylprostaglandin E1;(±)-15-Deoxy-(16RS)-16-hydroxy-16-methylprostaglandin E1 methyl ester

CAS NO.:59122-46-2

Empirical Formula: C22H38O5

Molecular Weight: 382.54

MDL number: MFCD07772001

EINECS: 664-288-5

Pack Size Price Stock Quantity
1ml RMB559.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 261-263°C
Boiling point: 429.67°C (rough estimate)
Density  1.0323 (rough estimate)
refractive index  1.6120 (estimate)
storage temp.  Sealed in dry,Store in freezer, under -20°C
solubility  Practically insoluble in water, soluble in ethanol (96 per cent), sparingly soluble in acetonitrile.
pka 13.92±0.60(Predicted)

Description and Uses

Misoprostol is an orally-active PGEl analog useful in the treatment of gastric and duodenal ulcers. As with other agents of this type, misoprostol may prove useful as a gastric cytoprotective when administered concurrently with irritating drugs such as nonsteroidal antiinflammatories.

Misoprostol is a cytoprotective prostaglandin PGE1 analogue that inhibits gastric acid secretion. It has many medical uses, including nine obstetric indications. The drug was originally produced by Pfizer for the treatment of gastric ulcers. Misoprostol is commonly used to prevent NSAID-induced gastric ulcers in patients at high risk of complications from a gastric ulcer, such as elderly patients and patients with a history of ulcer. It has also been used in treating duodenal ulcers unresponsive to histamine H2-antagonists; the drug does not prevent duodenal ulcers,however, in patients taking NSAIDS. Misoprostol can cause miscarriage, often associated with potentially dangerous bleeding.

Safety

Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H360
Precautionary statements  P201-P280-P301+P330+P331+P310-P308+P313
Hazard Codes  T
Risk Statements  45-60-61-25-36/37/38
Safety Statements  53-22-36/37/39-45
RIDADR  UN 2810 6.1/PG 3
WGK Germany  2
RTECS  UK8390000
HS Code  2937500000
Toxicity LD50 in rats, mice (mg/kg): 40-62, 70-160 i.p.; 81-100, 27-138 orally (Kotsonis)

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