D(-)-Norgestrel , ≥99% , 797-63-7

Synonym(s):
Levonorgestrel;D(?)-Norgestrel;13β-Ethyl-17α-ethynyl-17β-hydroxygon-4-en-3-one;17α-Ethynyl-18-homo-19-nor-testosterone;18,19-Dinor-13β-ethyl-17β-hydroxy-4-pregnen-20-yn-3-one

CAS NO.：797-63-7

Empirical Formula: C21H28O2

Molecular Weight: 312.45

MDL number: MFCD06198806

EINECS: 212-349-8

PRODUCT Properties

• Melting point: 206°C
• alpha: D20 -32.4° (c = 0.496 in CHCl3)
• Boiling point: 392.36°C (rough estimate)
• Density: 1.0697 (rough estimate)
• refractive index: 1.4900 (estimate)
• storage temp.: Sealed in dry,2-8°C
• solubility: Practically insoluble in water, sparingly soluble in methylene chloride, slightly soluble in ethanol (96 per cent).
• pka: 13.09±0.40(Predicted)
• form: Solid
• color: Crystals from MeOH/CHCl3
• Water Solubility: 10mg/L(temperature not stated)
• Merck: 13,6736
• BCS Class: 1
• InChI: InChI=1/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21-/s3
• InChIKey: WWYNJERNGUHSAO-HABXDNTMNA-N
• SMILES: C([C@]12CC[C@]3([H])[C@@]4([H])CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@@]2(O)C#C)C |&1:1,4,6,16,18,22,r|

Description and Uses

Levonorgestrel exhibits some androgenic activity but no glucocortic oid or antimineraloc orticoid action. Levonorgestrel can be administered orally, transdermally (combined with estradiol and formulated as a 7-day patch), and for prolonged, continuous use, via an intrauterine device (IUD). The oral bioavailability of levonorgestrel is approximately 95%. From a protein binding pers pective, 48% of an oral dose is bound to SHBG, and 50% is bound to albumin. Levonorgestrel under goes metabolic reduction of its ketone and is hydroxylated.

progestin

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H351-H360D-H362
• Precautionary statements: P202-P260-P263-P264-P270-P308+P313
• Hazard Codes: Xn,T
• Risk Statements: 20/21/22-40-60
• Safety Statements: 22-36
• WGK Germany: 3
• RTECS: JF8225000
• HS Code: 2937230000