D(-)-Norgestrel , ≥99% , 797-63-7

Synonym(s):
Levonorgestrel;D(?)-Norgestrel;13β-Ethyl-17α-ethynyl-17β-hydroxygon-4-en-3-one;17α-Ethynyl-18-homo-19-nor-testosterone;18,19-Dinor-13β-ethyl-17β-hydroxy-4-pregnen-20-yn-3-one

CAS NO.：797-63-7

Empirical Formula: C21H28O2

Molecular Weight: 312.45

MDL number: MFCD06198806

EINECS: 212-349-8

PRODUCT Properties

• Melting point: 206°C
• alpha: D20 -32.4° (c = 0.496 in CHCl3)
• Boiling point: 392.36°C (rough estimate)
• Density: 1.0697 (rough estimate)
• refractive index: 1.4900 (estimate)
• storage temp.: Sealed in dry,2-8°C
• solubility: Practically insoluble in water, sparingly soluble in methylene chloride, slightly soluble in ethanol (96 per cent).
• form: Solid
• pka: 13.09±0.40(Predicted)
• color: Crystals from MeOH/CHCl3
• Water Solubility: 10mg/L(temperature not stated)
• Merck: 13,6736
• BCS Class: 1
• InChI: InChI=1/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21-/s3
• InChIKey: WWYNJERNGUHSAO-HABXDNTMNA-N
• SMILES: C([C@]12CC[C@]3([H])[C@@]4([H])CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@@]2(O)C#C)C |&1:1,4,6,16,18,22,r|
• CAS DataBase Reference: 797-63-7(CAS DataBase Reference)

Description and Uses

Levonorgestrel exhibits some androgenic activity but no glucocortic oid or antimineraloc orticoid action. Levonorgestrel can be administered orally, transdermally (combined with estradiol and formulated as a 7-day patch), and for prolonged, continuous use, via an intrauterine device (IUD). The oral bioavailability of levonorgestrel is approximately 95%. From a protein binding pers pective, 48% of an oral dose is bound to SHBG, and 50% is bound to albumin. Levonorgestrel under goes metabolic reduction of its ketone and is hydroxylated.

progestin

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H351-H360D-H362
• Precautionary statements: P202-P260-P263-P264-P270-P308+P313
• Hazard Codes: Xn,T
• Risk Statements: 20/21/22-40-60
• Safety Statements: 22-36
• WGK Germany: 3
• RTECS: JF8225000
• HS Code: 2937230000
• Hazardous Substances Data: 797-63-7(Hazardous Substances Data)