Metronidazole , Analysis of standards,> 99.8%(HPLC) , 443-48-1

Synonym(s):
2-Methyl-5-nitroimidazole-1-ethanol;MTZ

CAS NO.：443-48-1

Empirical Formula: C6H9N3O3

Molecular Weight: 171.15

MDL number: MFCD00009750

EINECS: 207-136-1

PRODUCT Properties

• Melting point: 159-161 °C (lit.)
• Boiling point: 301.12°C (rough estimate)
• Density: 1.3994 (rough estimate)
• refractive index: 1.5800 (estimate)
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: acetic acid: 0.1 M, clear, faintly yellow
• form: crystalline
• pka: pKa 2.62(H2O,t =25±0.2,Iundefined) (Uncertain)
• color: white to light yellow
• Water Solubility: <0.1 g/100 mL at 20 ºC
• Merck: 14,6157
• BRN: 611683
• BCS Class: 1,3
• Stability: Stable. Incompatible with strong oxidizing agents.
• InChIKey: VAOCPAMSLUNLGC-UHFFFAOYSA-N
• LogP: -0.02
• NIST Chemistry Reference: Metronidazole(443-48-1)
• IARC: 2B (Vol. 13, Sup 7) 1987
• EPA Substance Registry System: Metronidazole (443-48-1)

Description and Uses

Metronidazole is a nitroimidazole antibiotic first isolated in the 1950s. Many nitroimidazoles were being studied at the time, as the class was found to have trichomonacidal properties. Metronidazole was of particular interest due to its high activity against Trichomonas vaginalis and Entamoeba histolytica both in vitro and in vivo as well as clinical activity against many anaerobic pathogens including Gram-positive and Gramnegative bacteria and Giardia lamblia. Metronidazole is often used clinically for intra-abdominal infections and is the firstline treatment for Clostridium difficile–associated diarrhea.

Metronidazole, is an antibiotic and antiprotozoal agent. It is mainly used to treat or prevent systemic or local infections caused by anaerobic bacteria, such as anaerobic bacterial infections in the abdominal cavity, digestive tract, female reproductive system, lower respiratory tract, skin and soft tissues, bones and joints, etc. Inflammation, meningeal infections, and colitis caused by antibiotic use are also effective. Tetanus is often treated with tetanus antitoxin (TAT). It can also be used for oral anaerobic infection. On October 27, 2017, the list of carcinogens published by the World Health Organization's International Agency for Research on Cancer was preliminarily sorted for reference, and metronidazole was included in the list of class 2B carcinogens. In January 2020, metronidazole was selected into the second batch of national centralized drug procurement list.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H340-H350-H373
• Precautionary statements: P202-P260-P280-P308+P313-P405-P501
• Hazard Codes: Xn
• Risk Statements: 40-46-45-39/23/24/25-23/24/25-11
• Safety Statements: 36/37-45-53-16-7
• WGK Germany: 3
• RTECS: NI5600000
• F: 8
• HS Code: 29332990
• Hazardous Substances Data: 443-48-1(Hazardous Substances Data)