Trimethoprim , ≥99% , 738-70-5

Synonym(s):
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine;NSC 106568

CAS NO.：738-70-5

Empirical Formula: C14H18N4O3

Molecular Weight: 290.32

MDL number: MFCD00036761

EINECS: 212-006-2

PRODUCT Properties

• Melting point: 199-203 °C
• Boiling point: 432.41°C (rough estimate)
• Density: 1.1648 (rough estimate)
• refractive index: 1.6000 (estimate)
• storage temp.: 2-8°C
• solubility: DMSO: soluble
• form: white powder
• pka: 6.6(at 25℃)
• color: colorless or white
• Water Solubility: <0.1 g/100 mL at 24 ºC
• Merck: 14,9709
• BRN: 625127
• BCS Class: 2
• Stability: Stable. Incompatible with strong oxidizing agents, acids.

Description and Uses

Trimethoprim selectivity between bacterial and mammalian dihydrofolate reductases results from the subtle but significant architectural differences between these enzyme systems. Whereas the bacterial enzyme and the mammalian enzyme both efficiently catalyze the conversion of dihydrofolic acid to tetrahydrofolic acid, the bacterial enzyme is sensitive to inhibition by trimethoprim by up to 40,000-fold lower concentrations than the mouse enzyme is. This difference explains the useful selective toxicity of trimethoprim.

anti-inflammatory

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Hazard Codes: T
• Risk Statements: 25
• Safety Statements: 45-24/25
• RIDADR: 3249
• WGK Germany: 3
• RTECS: UV8225000
• F: 8-10-21
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29335995
• Toxicity: LD50 orally in mice: 7000 mg/kg (Yamamoto)