≥98%(HPLC),powder , 138605-00-2

Synonym(s):
6-(3-Dimethylaminopropionyl)forskolin, HCl, Colforsin Daropate, HCl;6-[3-(dimethylamino)propionyl]-forskolin;Colforsin dapropate hydrochloride;Forskolin, NKH477 - CAS 138605-00-2 - Calbiochem;N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester b-Alanine hydrochloride

CAS NO.：138605-00-2

Empirical Formula: C27H44ClNO8

Molecular Weight: 546.09

MDL number: MFCD00236421

PRODUCT Properties

• storage temp.: 2-8°C
• solubility: H2O: soluble3mg/mL, clear to slightly hazy (warmed)
• form: White solid
• color: white to beige
• Water Solubility: Soluble to 40 mM in water

Description and Uses

Colforsin daropate was launched in Japan as a treatment for acute heart failure. It is a water-soluble and orally active 3-dimethylaminopropionyl (daropate) derivative of forskolin, a labdane-type diterpene isolated from the root of Coleus forskohlii. It is obtained from forskolin in 7 steps based upon a series of protections and deprotections of the different OH groups and a key 7,8- transacylation. Colforsin daropate is the first in its class of adenylate cyclase activators to be marketed in the treatment of heart failure. As forskolin, it directly stimulates adenylate cyclase thus increasing intracellular concentration of cAMP and inhibiting calcium mobilization. As a direct consequence, it induces a significant vasodilatation, so provides a moderate positive inotropic and chronotropic effect. In contrast with well-established generators of cAMP synthesis (dobutamine), Colforsin daropate maintains its action on cardiac muscle in the severe stage even when the beta-adrenoceptor is down-regulated in myocardium. In several clinical trials in patients with severe congestive heart failure (CHF), Colforsin daproate improved hemodynamic symptoms of heart failure patients without serious adverse effects.

NKH 477 is a water-soluble analog of Forskolin (F701800), that is a potent activator of adenylyl cyclase, which shows some selectivity for cardiac (type V) adenylyl cyclase).

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H300
• Precautionary statements: P264-P270-P301+P310-P405-P501
• Hazard Codes: T+
• Risk Statements: 28
• Safety Statements: 28-36/37-45
• RIDADR: UN 2811 6.1 / PGII
• WGK Germany: 3
• RTECS: AY5992600