Forskolin , ≥98% , 66575-29-9
Synonym(s):
7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one;7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxy-labd-14-en-11-one, Colforsin;Coleonol;Colforsin;Forskolin, Coleus forskohlii - CAS 66575-29-9 - Calbiochem
CAS NO.：66575-29-9
Empirical Formula: C22H34O7
Molecular Weight: 410.5
MDL number: MFCD00082317
EINECS: 266-410-9
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB31.20 | In Stock |
|
| 50MG | RMB119.20 | In Stock |
|
| 100MG | RMB193.60 | In Stock |
|
| 500mg | RMB552.00 | In Stock |
|
| 1g | RMB812.80 | In Stock |
|
| 5g | RMB2420.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 282-232 °C |
| Boiling point: | 520℃ |
| alpha | D25 -26.19° (c = 1.68 in CHCl3) |
| Density | 1.23 |
| refractive index | 1.5300 (estimate) |
| Flash point: | 172℃ |
| storage temp. | room temp |
| solubility | DMSO: 5 mg/mL stable at least 6 months at room temperature |
| form | powder |
| pka | 11.00±0.70(Predicted) |
| color | off-white |
| Water Solubility | Soluble in ethanol, dimethylsulfoxide and chloroform. Insolule in water. |
| λmax | 305nm(lit.) |
| Merck | 14,2476 |
| BRN | 1692716 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months. |
| InChIKey | OHCQJHSOBUTRHG-KGGHGJDLSA-N |
| LogP | 2.406 (est) |
| CAS DataBase Reference | 66575-29-9 |
Description and Uses
Forskolin (66575-29-9) is a widely used adenylate cyclase activator.1 Forskolin also is a positive inotropic agent, vasodilator and induces platelet activation among other activities.2-5
Cyclic AMP (cAMP) is an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals Forskolin is a naturally occurring diterpene that is produced by the Indian Coleus plant (C. forskohlii). It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. Forskolin binds to adenylyl cyclase in membranes from stably transfected Sf9 cells expressing type 1 adenylyl cyclase with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 μM in an activation assay assessing formation of cAMP from ATP. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling.[Cayman Chemical]
