Hypericin , 10mMinDMSO , 548-04-9
Synonym(s):
4,5,7,4′,5′,7′-Hexahydroxy-2,2′-dimethylnaphthodianthrone;Casein Kinase II Inhibitor XI;Cyclo werrol;Hypericin - CAS 548-04-9 - Calbiochem;Hypericum red
CAS NO.：548-04-9
Empirical Formula: C30H16O8
Molecular Weight: 504.44
MDL number: MFCD00016683
EINECS: 208-941-0
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 299-301°C |
| Boiling point: | 1020.3±65.0 °C(Predicted) |
| Density | 1.915±0.06 g/cm3(Predicted) |
| RTECS | SF8472000 |
| storage temp. | -20°C |
| solubility | 1 M NaOH: 10 mg/mL |
| form | powder |
| pka | 6.91±0.20(Predicted) |
| color | black |
| Water Solubility | Soluble in ethanol, dimethyl sulfoxide, methanol, acetone, ethylmethylketone, pyridine and sodium hydroxide. Insoluble in water. |
| Sensitive | Light Sensitive |
| Merck | 14,4863 |
| BRN | 1917913 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChIKey | BTXNYTINYBABQR-UHFFFAOYSA-N |
| LogP | 10.827 (est) |
| CAS DataBase Reference | 548-04-9(CAS DataBase Reference) |
Description and Uses
An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John’s wort) and has antidepressant, antiviral, and anticancer activities. Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects. It exerts broad spectrum phototoxic affects (IC50 = 140 - 1,570 nM) through induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells. Hypericin also has in vitro activity, which can be enhanced with photo-activation, against a variety of viruses including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses.
It was used as reference standard in determining hypericins in St. John′s Wort using HPLC method.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22-40-43 |
| Safety Statements | 22-36-36/37 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| F | 8 |
| HS Code | 29145090 |
