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A4720012

Hypericin , Analysis of standard products, ≥96% , 548-04-9

Synonym(s):
4,5,7,4′,5′,7′-Hexahydroxy-2,2′-dimethylnaphthodianthrone;Casein Kinase II Inhibitor XI;Cyclo werrol;Hypericin - CAS 548-04-9 - Calbiochem;Hypericum red

CAS NO.:548-04-9

Empirical Formula: C30H16O8

Molecular Weight: 504.44

MDL number: MFCD00016683

EINECS: 208-941-0

Pack Size Price Stock Quantity
10MG RMB623.20 In Stock
25mg RMB1231.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 299-301°C
Boiling point: 1020.3±65.0 °C(Predicted)
Density  1.915±0.06 g/cm3(Predicted)
RTECS  SF8472000
storage temp.  -20°C
solubility  1 M NaOH: 10 mg/mL
form  powder
pka 6.91±0.20(Predicted)
color  black
Water Solubility  Soluble in ethanol, dimethyl sulfoxide, methanol, acetone, ethylmethylketone, pyridine and sodium hydroxide. Insoluble in water.
Sensitive  Light Sensitive
Merck  14,4863
BRN  1917913
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey BTXNYTINYBABQR-UHFFFAOYSA-N
LogP 10.827 (est)

Description and Uses

An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John’s wort) and has antidepressant, antiviral, and anticancer activities. Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects. It exerts broad spectrum phototoxic affects (IC50 = 140 - 1,570 nM) through induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells. Hypericin also has in vitro activity, which can be enhanced with photo-activation, against a variety of viruses including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses.

It was used as reference standard in determining hypericins in St. John′s Wort using HPLC method.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn
Risk Statements  22-40-43
Safety Statements  22-36-36/37
RIDADR  2811
WGK Germany  3
8
HS Code  29145090

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