Apigenin-d5(Major) , AR , 263711-74-6
| Pack Size | Price | Stock | Quantity |
| 50mg | RMB2537.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 345-350°C |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly) |
| form | Solid |
| color | Pale Yellow to Yellow |
Description and Uses
Apigenin-d5 is an internal standard for the quantificaiton of apigenin by GC- or LC-MS. Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 μM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 μM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI-231 cells. Apigenin, at 5 μM, is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.
The labelled aglucon of apiin and of apigenin-7-glucoside
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 |
