Home Categories Apigenin-d5(Major)
M9297434

Apigenin-d5(Major) , AR , 263711-74-6

CAS NO.:263711-74-6

Empirical Formula: C15H5D5O5

Molecular Weight:

MDL number:

Pack Size Price Stock Quantity
50mg RMB2537.60 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: 345-350°C
storage temp.  -20°C Freezer
solubility  DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly)
form  Solid
color  Pale Yellow to Yellow

Description and Uses

Apigenin-d5 is an internal standard for the quantificaiton of apigenin by GC- or LC-MS. Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 μM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 μM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI-231 cells. Apigenin, at 5 μM, is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.

The labelled aglucon of apiin and of apigenin-7-glucoside

Safety

RELATED PRODUCTS