Skepinone-L , 99% , 1221485-83-1
CAS NO.：1221485-83-1
Empirical Formula: C24H21F2NO4
Molecular Weight: 425.42
MDL number: MFCD22572738
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB1459.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 130-134°C |
| Boiling point: | 629.0±55.0 °C(Predicted) |
| Density | 1.384±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 13.49±0.20(Predicted) |
| form | Solid |
| color | Light Yellow to Yellow |
Description and Uses
Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 μM). It has little effect on a range of other kinases, including p38γ and p38δ. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK substrate, in response to stimulation with anisomycin in HeLa cells (IC50 = 25 nM) or TNF-α in THP-1 cells. At 1 μM, it prevents phosphorylation of cytosolic phospholipase A2 in platelets in response to collagen-related peptide or thrombin , blunting platelet secretion and aggregation.
Skepinone-L is a potent and highly selective inhibitor of p38 MAP kinase which impairs platelet activation and thrombus formation.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2922500090 |
