M4030835
MK-2461 , 98% , 917879-39-1
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB511.20 | In Stock |
|
| 5mg | RMB1337.60 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 192-193 °C |
| Boiling point: | 732.4±70.0 °C(Predicted) |
| Density | 1.45±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≥24.8 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| form | solid |
| pka | 6.81±0.20(Predicted) |
| color | Light yellow to yellow |
Description and Uses
MK-2461 is a novel ATP-competitive multitargeted kinase inhibitor that preferentially inhibits the activated c-Met receptor. MK-2461 is also a potent inhibitor of Ron, Flt1, Flt 3, PDGFRβ, and Mer receptors. Recent studies show that MK-2461 siginifciantly suppresses tumor growth of GTL-16 xenografts in mice and MK-2461 treatments effectively inhibit the growth of NIH3T3 tumors harboring c-Met single nucleotide mutants T3936C and T3997C.
