Sitafloxacin Sesquihydrate , 99+% , 163253-35-8

Synonym(s):
7-[(7S)-7-Amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, hydrate (2:3)

CAS NO.：163253-35-8

Empirical Formula: C19H18ClF2N3O3.H2O

Molecular Weight: 427.833

MDL number:

EINECS: 1308068-626-2

PRODUCT Properties

• Melting point: 145-147°C (dec.)
• alpha: 589 -199.9°
• storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• solubility: Aqueous Base (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated)
• form: Solid
• color: White to Off-White
• Stability: Hygroscopic
• InChIKey: ANCJYRJLOUSQBW-UWQPBFEBNA-N
• SMILES: N[C@@H]1CN(C2=C(C=C3C(=O)C(C(=O)O)=CN([C@@H]4C[C@@H]4F)C3=C2Cl)F)CC21CC2.O |&1:1,16,18,r|
• CAS DataBase Reference: 163253-35-8(CAS DataBase Reference)

Description and Uses

The fluoroquinolone antibacterial agent sitafloxacin hydrate was developed by Daiichi Sankyo and was approved and launched last year in Japan. Sitafloxacin’s mode of action is through inhibition of DNA gyrase and topoisomerase IV. It is indicated for the treatment of inflammatory infections such as laryngopharyngitis, adenoiditis, acute bronchitis, pneumonia, secondary infections due to chronic respiratory lesions, cystitis, pyelonephritis, urethritis, cervicitis, otitismedia, sinusitis, periodontitis, and pericoronitis and jaw inflammation. Due to its broad spectrum of potent antibacterial activity, sitafloxacin is expected to be clinically effective in treating severe cases of bacterial infection, relapse/recrudescence of infection and infections in which resistant bacteria are suspected to be the cause.

Antibacterial

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• HS Code: 2941900000