SU11274 , 98% , 658084-23-2

Synonym(s):
(3Z)-N-(3-Chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide, SU11274;Met Kinase Inhibitor - CAS 658084-23-2 - Calbiochem

CAS NO.：658084-23-2

Empirical Formula: C28H30ClN5O4S

Molecular Weight: 568.09

MDL number: MFCD08276928

PRODUCT Properties

• Density: 1.401±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: 10 mg/mL at 60 °C
• pka: 11.62±0.20(Predicted)
• form: powder
• color: orange
• InChIKey: FPYJSJDOHRDAMT-KQWNVCNZSA-N

Description and Uses

MET is a proto-oncogene which encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in many types of cancer. SU11274 is a potent, selective, ATP-competitive inhibitor of c-Met (IC₅₀ = 20 nM). It has much less or no activity against other receptor tyrosine kinases. SU11274 induces apoptosis and cell cycle arrest in transformed Ba/F3 cells and cancer cell lines.

SU 11274 is a competitive inhibitor of Met kinase activity.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H335-H315-H319
• Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3